2020骞翠腑绱氫富绠¤(h霉)甯珮闋昏€冮粸(di菐n)鍏�(n猫i)瀹癸細鍏嬮浄浼】鑿岃偤鐐庣殑闋�(y霉)闃茶(h霉)鐞�
鍏嬮浄浼】鑿岃偤鐐庣殑闋�(y霉)闃茶(h霉)鐞嗭細
1.鍤�(y谩n)鏍煎煼(zh铆)琛屾秷姣掕垏闅旈洟鍒跺害
閫欎富瑕佹槸閲濆皪閱�(y墨)鍕�(w霉)浜哄摗鍙婇櫌鍏�(n猫i)鐠�(hu谩n)澧�銆佸櫒姊拌€岃█锛屾帴瑙哥梾浜哄墠鍚庡毚(y谩n)鏍兼礂鎵�銆佹埓鎵嬪鎿嶄綔锛屽畾鏈熺挵(hu谩n)澧冨強瀹ゅ収(n猫i)娑堟瘨閫氶ⅷ(f膿ng)锛屾寜鐓ц姹傚畾鏈熸竻娲�銆佹秷姣掑懠鍚告不鐧傝缃紝瀹氭湡鏇存彌姗�(j墨)姊伴€氭埃鍙婇湩鍖栧櫒绠¤矾绛�锛岄噰鍙栦竴鏁村鍤�(y谩n)鏍肩殑闄㈠収(n猫i)鎰熸煋鐩�(ji膩n)娓拰闋�(y霉)闃茶▓鍔�銆傛摎(j霉)鍫遍亾锛岄噰鍙栭€欎竴瑷堝妰鐨勯啱(y墨)闄㈣垏鏈噰鍙栫殑閱�(y墨)闄㈡瘮杓�锛岄櫌鍏�(n猫i)鎰熸煋鐜囦綆20%銆�
2.鑳冭吀閬撳幓姹℃不鐧�
閫欐槸杩戝勾渚嗘瓙娲插父鐢ㄧ殑涓€绋爯(y霉)闃叉帾鏂斤紝涓昏鏄嚌灏嶉櫌鍏�(n猫i)鎰熸煋鐨勬槗鎰熶汉缇�锛岀洰鐨勬槸鍘婚櫎鑳冭吀鍏�(n猫i)鐨勮弻钀藉瘎娈栬垏鐢熼暦銆傛柟娉曟湁鍏ㄨ儍鑵稿幓姹″拰閬告搰鎬ц儍鑵稿幓姹℃硶锛屽父鐢ㄧ殑鐐哄悗鑰�锛屽畠閫氶亷榧婚<鎴栧彛鏈嶈儍鑵镐笉鍚告敹鐨勫绮樿弻绱燘銆佸Ε甯冮湁绱�(鎱跺ぇ闇夌礌鎴栨柊闇夌礌绛�)鍙婁簩鎬ч湁绱燘锛岄€g敤5澶╋紝骞舵瘡澶╃郴绲�(t菕ng)鎳�(y墨ng)鐢ㄩ牠瀛㈣弻绱�锛屽緸鍙e捊閮ㄥ強鑳冭吀閬撲腑鍘婚櫎闇€姘ц弻鑰屼笉闄嶄綆鍘哀鑿岀殑鏁�(sh霉)閲忥紝鍏堕爯(y霉)闃蹭綔鐢ㄥ湪闈╄槶闄版€ф】鑿屾柟闈㈠挨鐐烘槑椤�锛屾摎(j霉)浣滆€呯当(t菕ng)瑷堟湁闂�(gu膩n)鏂囩嵒(xi脿n)锛屽幓姹$祫骞句箮鐒$辜鐧�(f膩)鎬ц偤鐐庡厠闆风櫧妗胯弻鐨勮偤鐐庤垏鍛煎惛閬撴劅鏌�(鍊嬪垾鐐鸿€愯棩鏍劅鏌�)銆�
鍏嬮浄浼】鑿岃偤鐐庣殑闋�(y霉)闃茶(h霉)鐞嗭細
3.淇濊(h霉)鑳冮儴閰告€у睆闅�
涓昏鏄湪闋�(y霉)闃叉噳(y墨ng)婵€鎬ф桨鐦嶆檪锛屾噳(y墨ng)鐢ㄧ~绯栭媮(ulcerlmin)椤炶棩鐗�锛屽畠鏃㈠彲浠ラ槻姝㈡噳(y墨ng)婵€鎬ф桨鐦嶅嚭琛€锛屽張鍥犲畠鍏锋湁鍚搁檮鑳冮粡鑶溿€佹敼璁婅儍榛忔恫銆佸鍔犺儍鑵斾腑鍓嶅垪鑵虹礌E2(PGE2)鍚噺銆佸惛鏀惰儍铔嬬櫧閰剁殑浣滅敤锛屽苟涓嶆敼璁婅儍鍏�(n猫i)閰告€х挵(hu谩n)澧�锛屽緸鑰屾湁鏁堝湴璧峰埌浜嗛槻姝�?ji茅)顫厳鑳轰箰鍨㈣叆闀滄窎楗�?鑰屼笖鎿�(j霉)鏂囩嵒(xi脿n)浠嬬垂锛岀~绯栭媮灏氬叿鏈夊収(n猫i)鍦ㄧ殑娈鸿弻娲绘€�锛屼竴绯诲垪鐮旂┒琛ㄦ槑鎳�(y墨ng)鐢ㄦ姉閰稿姂绲勭殑鑲虹値鐧�(f膩)鐢熺巼鐐�23%锝�35%锛岃€屾噳(y墨ng)鐢ㄧ~绯栭媮绲勮偤鐐庣殑鐧�(f膩)鐢熺巼鐐�10%锝�19%銆�
4.鐢熺墿闋�(y霉)闃�
鑲虹値鍏嬮浄鐧芥】鑿岃偤鐐庣殑鐢熺墿闋�(y霉)闃叉柟娉曞皻铏曚簬瀵�(sh铆)椹�(y脿n)闅庢銆侶eld绛夊埄鐢ㄨ嚜鑲虹値鍏嬮浄鐧芥】鑿岃帰鑶滃绯�(CPS)瑾樺皫(d菐o)鐢�(ch菐n)鐢熺殑IgM鍠厠闅嗘姉楂�(MAb)娉ㄥ皠绲﹀(sh铆)椹�(y脿n)鍕曠墿浠ラ爯(y霉)闃茶偤鐐庡厠闆风櫧妗胯弻鑲虹値锛岃垏灏嶇収绲勬瘮杓�锛岀劇璜栧櫒瀹樺彈绱巼銆佹劅鏌撶祫绻旂殑绱�(x矛)鑿屾暩(sh霉)閲�銆佽偤鍏�(n猫i)绲勭箶瀛�(xu茅)鏀硅畩绛夎鏂归潰锛岄爯(y霉)闃茬祫閬�(yu菐n)鍎�(y艒u)浜庡皪鐓х祫(P<0.01)锛屼絾閫欑óMAb灏氱劇闃绘鑲虹値鍏嬮浄鐧芥】鑿岄€�(j矛n)鍏ヨ偤鍏�(n猫i)鐨勪綔鐢�锛岃€屾槸鍔犻€熸劅鏌撳惛鏀�锛屽寮�(qi谩ng)鑲虹殑鎺掕弻鑳藉姏銆傚彟澶栧皻鏈変竴浜涢浼肩殑瀵�(sh铆)椹�(y脿n)鍫卞憡锛屼絾鎴愮啛鐨勭柅鑻楀強鎶楅珨灏氭湭鎳�(y墨ng)鐢ㄤ簬鑷ㄥ簥锛岄渶閫�(j矛n)涓€姝ョ爺绌躲€�
鑲虹値鍏嬮浄鐧芥】鑿岃偤鐐庡嵄瀹充汉椤炲凡涓€鍊嬪涓栫磤(j矛)锛岄毃钁楃瀛�(xu茅)鐨勭櫦(f膩)灞�锛屾鏌ュ強娌荤檪鎵嬫鐨勪笉鏂峰畬鍠�锛屼汉椤炲皪鍏朵簡瑙g殑閫愭娣卞叆锛岀浉淇″彲浠ラ€�(j矛n)涓€姝ラ檷浣庡畠鐨勭櫦(f膩)鐥呯巼鍙婄梾姝荤巼锛屽彇寰楁洿澶х殑閫�(j矛n)姝�銆�
浠ヤ笂灏辨槸2020骞翠腑绱氫富绠¤(h霉)甯珮闋昏€冮粸(di菐n)鍏�(n猫i)瀹癸細鍏嬮浄浼】鑿岃偤鐐庣殑闋�(y霉)闃茶(h霉)鐞嗭紒鐐轰簡绡€(ji茅)绱勫ぇ瀹剁殑寰�(f霉)缈�(x铆)鏅傞枔锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍″皬绶ㄧ偤澶у鏁寸悊浜嗚垏涓荤璀�(h霉)甯€冭│鐩搁棞(gu膩n)鐨勫悇瀛�(xu茅)绉戣€冭│澶х侗銆佹骞寸湡椤岀瓑鍏�(n猫i)瀹癸紝榛�(di菐n)鎿婁笅鏂规寜閳曞嵆鍙�鍏嶈不(f猫i)涓嬭級锛岀澶у閮借兘鑰冨彇濂芥垚绺俱€備竴璧峰姞娌瑰京(f霉)缈�(x铆)鍚�锛屾渶鍚庢矕鍒轰簡锛�
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